Utilizing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration passions consist of:
You frequently get involved in conversations about science and faith. You may have also composed quite a few publications on the topic. Don’t you are convinced at some time We're going to know almost everything and that God’s position will be around?
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I am able to barely picture how I, like a geneticist, would have the capacity to understand basic physics, let alone compete at the best. How did you go about this?
2015, discovery that condensin can be a very adaptable protein framework; and 1st detection of DNA knots utilizing nanopores
Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim with the pore is highlighted in crimson, along with a 3D rendering of your motion of the DNA rod is shown.
We form germs into forms that deviate from their natural phenotype. Precisely, I'll demonstrate our capability to shape Are living E. coli micro organism into novel designs like rectangles, squares, triangles and circles.
2000, discovery that nanotubes can carry amazing large existing densities; fixed the controversial issue of electronic transportation as a result of DNA molecules by measurements of insulating behavior at The only molecule amount; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
‘You should not just consider the concerns of tomorrow, but additionally take into account the inquiries on the day right after tomorrow’
Dekker started out his research on one carbon nanotubes in 1993 when he create a brand new line of investigate to review electrical transport by single natural and organic molecules among nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was reached inside a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography techniques have been used to exhibit that these nanotubes are quantum wires at the single-molecule stage, with excellent Actual physical Qualities.
[fourteen] In 2005 Dekker turned associated with Netherlands-large discussions about Smart Design, a motion that he has because Plainly distanced himself from. Dekker advocates that science and faith usually are not in opposition but is usually harmonized.
2006, first demonstration of molecular sorting within a lab over a chip using biomotors; discovery of nanobubbles in cees dekker sound-condition nanopores; and to start with estimate of electrokinetic Power conversion within a nanofluidic channel
2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-variety conformational improvements in Mre11/DNA restore complexes; and 1st pressure measurements on the DNA molecule inside a nanopore
Solid-state nanopores have proven to be a astonishingly functional probe for solitary-molecule Assessment of DNA. I'll explain several of our modern results – especially DNA knots – along with our initiatives to grow the abilities of sound-state nanopores even additional, within the direction of one-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.